Independent Career


23. B. Zoller, J. Zapp, P. H. Huy,* "Rapid Organocatalytic Formation of Carbon Monoxide: Application towards Carbonylative Cross Couplings", Chem. Eur. J. 2020, doi: 10.1002/chem.202002746.

22. P. H. Huy, Radikale durch Licht – molekularer Baukasten für komplexe Moleküle", Nachr. Chem. 202068(1), 80-84 (review, doi: 10.1002/nadc.20204089927). An English translation can be found below.

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21. P. H. Huy, "Lewis Base Catalysis Promoted Nucleophilic Substitutions - Recent Advances and Future Directions", Eur. J. Org. Chem. 2020, 10-27 (review, very important paper, doi: 10.1002/ejoc.201901495, Cover Feature).


20. P. H. Huy,* P. Grewelinger, Nicht essen, nur schauen – polyhalogenierte Naturstoffe aus Algen“, Nachr. Chem. 201967(9), 63-67 (short review, doi: 10.1002/nadc.20194089372). English translation entitled "Beautiful but Toxic – Polyhalogenated Natural Products from Algae" available below.

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19. P. Huy, C. Czekelius in Science of Synthesis Knowledge Updates (Eds. H.-U. Reissig, E. Schaumann), Thieme Stuttgart, 2019, Vol. 2, “Chapter 32.4.4: Chloro, Bromo and Iodoalkanes”, 91-241 (review, doi: 10.1055/sos-SD-132-00171).

18. P. H. Huy,* C. Mbouhom, “Formamide Catalyzed Activation of Carboxylic Acid Chlorides: Versatile and Cost-Efficient Amidation and Esterification“, Chem. Sci. 2019, 10, 7399-7406 (doi: 10.1039/C9SC02126D).

Highlighted in H. Yamamoto, M. Chaithanya, Synfacts 2019, 15, 1204 and on

17. P. H. Huy,* B. Zoller, "Blickpunkt Synthese - Bor-Lewis-Säurekatalyse: Amide atomeffizient synthetisieren“, Nachr. Chem. 2019, 67(5), 51-54 (doi: 10.1002/nadc.20194087418, short review in German, English Translation available: "Boron Lewis Acid Catalysis: How to Synthesize Amides Atom-Efficiently").

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16. P. H. Huy, “Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides”, Synthesis 2019, 51, 2474–2483 (doi: 10.1055/s-0037-1611798). Highlighted on


15. S. Motsch, C. Schütz, P. H. Huy,* “Systematic Evaluation of Sulfoxides as Catalysts in Nucleophilic Substitutions of Alcohols“, Eur. J. Org. Chem. 2018, 4541-4547 (doi: 10.1002/ejoc.201800907). Selected as very important paper.

14. T. Stach, J. Dräger, P. H. Huy,* „Nucleophilic Substitutions of Alcohols in High Catalytic Efficiency“, Org. Lett. 2018, 20, 2980-2983 (doi: 10.1021/acs.orglett.8b01023). Highlighted on

13. P. H. Huy,* I. Filbrich, „A General Catalytic Method for Nucleophilic Substitutions in High Cost- and Atom-Efficiency“, Chem. Eur. J. 2018, 24, 7410–7416 (doi: 10.1002/chem.201800588, hot paper).


12. P. H. Huy,* T. Hauch, I. Filbrich, "Lewis Base Catalyzed Nucleophilic Substitutions of Alcohols”, Synlett 2016, 27, 2631-2636 (doi: 10.1055/s-0036-1588633).

11. P. H. Huy,* S. Motsch, S. M. Kappler, "Formamide als Lewis-Basen-Katalysatoren in SN-Reaktionen: Effiziente Transformationen von Alkoholen zu  Chloriden, Aminen und Ethern“, Angew. Chem. 2016, 128, 10300-10304 (doi: 10.1002/ange.201604921); “Formamides as Lewis Base Catalysts in SN-Reactions - Efficient Transformation of Alcohols into Chlorides, Amines and Ethers”, Angew. Chem. Int. Ed. 2016, 55, 10145-10149 (doi: 10.1002/anie.201604921).

Highlighted in: Zhao, W.; Zhao, D.; Guizetti, S.; Schwindeman, J. A.; Daniels, D. S. B.; Guerrero, C.; Knight, J. Org. Process Res. Dev. 2016, 20, 1691-1701 (doi: 10.1021/acs.oprd.6b00321).


10. P. H. Huy, I. Filbrich (Saarland University), “Method of converting alcohol to halide”, LU patent 2017/93108 (Priority date 2016, June 16th).


9. P. H. Huy (Saarland University), “Method of converting alcohol to halide”, WO patent 2016/202894 A1 (Priority date 2015, June 17st).

Postdoc and PhD


8. R. Opitz, M. Müller, C. Reuter, M. Barone, A. Soicke, Y. Roske, K. Piotukh, P. Huy, M. Beerbaum, B. Wiesner, M. Beyermann, P. Schmieder, C. Freund, R. Volkmer, H. Oschkinat, H.-G. Schmalz,* R. Kühne,* "A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions“, Proc. Natl. Acad. Sci. USA 2015, 112, 5011-5016 ( doi: 10.1073/pnas.1422054112).



7. P. H. Huy,* J. Westphal, A. M. P. Koskinen,* "Concise, stereodivergent and highly stereoselective synthesis of cis- and trans-2-substituted 3-hydroxypiperidines – development of a phosphite-driven cyclodehydration”, Beilstein J. Org. Chem. 2014, 10, 369-383 (doi: 10.3762/bjoc.10.35).


6. P. H. Huy,* A. M. P. Koskinen,* "Efficient, Stereodivergent Access to 3-Piperidinols by traceless P(OEt)3-Cyclodehydration”, Org. Lett. 2013, 15, 5178-5181 (doi 10.1021/ol4026588).

5. R. Kühne, H. Oschkinat, R. Opitz, M. Müller, H.-G. Schmalz, C. Reuter, P. Huy, "Structural mimetics of proline-rich peptides and use of the same“, WO patent 2013/030111 A1.



4. C. Reuter, P. Huy, J.-M. Neudörfel, R. Kühne, H.-G. Schmalz,* "Exercises in Pyrrolidine Chemistry: Gram Scale Synthesis of a Pro-Pro Dipeptide Mimetic with a Polyproline Type II Helix Conformation“, Chem. Eur. J. 2011, 17, 12037-12044 (doi: 10.1002/chem.201101704).

3. P. Huy, H.-G. Schmalz,* “Practical One-pot Double Functionalizations of Proline”, Synthesis 2011, 954-960 (doi: 10.1055/s-0030-1258428).

2. P. Huy, J.-M. Neudörfl, H.-G. Schmalz,* "A Practical Synthesis of trans-3-substituted Proline Derivatives through 1,4-Addition”, Org. Lett. 2011, 13, 216-219 (doi: 10.1021/ol102613z).


1. J. Zaminer, C. Brockmann, P. Huy, R. Opitz, C. Reuter, M. Beyermann, C. Freund, M. Müller, H. Oschkinat, R. Kühne,* H.-G. Schmalz,* „Adressierung von Protein-Protein-Wechselwirkungen durch niedermolekulare Verbindungen: ein Pro-Pro-Dipeptid-mimetikum mit PPII-Helixkonformation als Modul für die Synthese PRD-bindender LigandenAngew. Chem. 2010, 122, 7265–7269; “Addressing Protein–Protein Interactions with Small Molecules: A Pro-Pro Dipeptide Mimic with a PPII Helix Conformation as a Module for the Synthesis of PRD-Binding Ligands“, Angew. Chem. Int. Ed. 2010, 49, 7111–7115 (doi: 10.1002/anie.20100173).