Independent Career

2020

25. Formamide-Catalyzed Nucleophilic Substitutions: Mechanistic Insight and Rationalization of Catalytic Activity / C. Kohlmeyer, S. Schäfer,* P. H. Huy,* G. Hilt,* ACS Catalysis 2020, doi: 10.1021/acscatal.0c03348.

24. Lewis Base Catalysis Enables the Activation of Alcohols by means of Chloroformates as Phosgene Substitutes / B. Zoller, T. Stach, P. H. Huy,* ChemCatChem 2020, doi: 10.1002/cctc.202001175.

Selected as part of the Young Researchers Series.

23. Rapid Organocatalytic Formation of Carbon Monoxide: Application towards Carbonylative Cross Couplings / B. Zoller, J. Zapp, P. H. Huy,* Chem. Eur. J. 2020226, 9632-9638.

(doi:  10.1002/chem.202002746)

22. Radikale durch Licht – molekularer Baukasten für komplexe Moleküle / P. H. Huy, Nachr. Chem. 202068(1), 80-84 (review, doi: 10.1002/nadc.20204089927). An English translation can be found below.

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21. Lewis Base Catalysis Promoted Nucleophilic Substitutions - Recent Advances and Future Directions / P. H. Huy,  Eur. J. Org. Chem. 2020, 10-27 (review, selected as very important paper, doi: 10.1002/ejoc.201901495, Cover Feature).



2019

20. Nicht essen, nur schauen – polyhalogenierte Naturstoffe aus Algen / P. H. Huy,* P. Grewelinger, Nachr. Chem. 201967(9), 63-67 (short review, doi: 10.1002/nadc.20194089372). English translation entitled "Beautiful but Toxic – Polyhalogenated Natural Products from Algae" available below.

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19. P. Huy, C. Czekelius in Science of Synthesis Knowledge Updates (Eds. H.-U. Reissig, E. Schaumann), Thieme Stuttgart, 2019, Vol. 2, “Chapter 32.4.4: Chloro, Bromo and Iodoalkanes”, 91-241 (review, doi: 10.1055/sos-SD-132-00171).

18. Formamide Catalyzed Activation of Carboxylic Acid Chlorides: Versatile and Cost-Efficient Amidation and Esterification / P. H. Huy,* C. Mbouhom, Chem. Sci. 2019, 10, 7399-7406 (doi: 10.1039/C9SC02126D).

Highlighted in H. Yamamoto, M. Chaithanya, Synfacts 2019, 15, 1204 and on organic-chemistry.org.

17. Blickpunkt Synthese - Bor-Lewis-Säurekatalyse: Amide atomeffizient synthetisieren / P. H. Huy,* B. Zoller, Nachr. Chem. 2019, 67(5), 51-54 (doi: 10.1002/nadc.20194087418, short review in German, English Translation available: "Boron Lewis Acid Catalysis: How to Synthesize Amides Atom-Efficiently").

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16. Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides / P. H. Huy, Synthesis 2019, 51, 2474–2483 (doi: 10.1055/s-0037-1611798). Highlighted on organic-chemistry.org.


2018

15. Systematic Evaluation of Sulfoxides as Catalysts in Nucleophilic Substitutions of Alcohols / S. Motsch, C. Schütz, P. H. Huy,* Eur. J. Org. Chem. 2018, 4541-4547 (doi: 10.1002/ejoc.201800907). Selected as very important paper.

14. Nucleophilic Substitutions of Alcohols in High Catalytic Efficiency / T. Stach, J. Dräger, P. H. Huy,* Org. Lett. 2018, 20, 2980-2983 (doi: 10.1021/acs.orglett.8b01023). Highlighted on organic-chemistry.org.

13. A General Catalytic Method for Nucleophilic Substitutions in High Cost- and Atom-Efficiency / P. H. Huy,* I. Filbrich, Chem. Eur. J. 2018, 24, 7410–7416 (doi: 10.1002/chem.201800588, hot paper, Cover Feature).


2016

12. Lewis Base Catalyzed Nucleophilic Substitutions of Alcohols / P. H. Huy,* T. Hauch, I. Filbrich, Synlett 2016, 27, 2631-2636 (doi: 10.1055/s-0036-1588633).

11. Formamide als Lewis-Basen-Katalysatoren in SN-Reaktionen: Effiziente Transformationen von Alkoholen zu  Chloriden, Aminen und Ethern / P. H. Huy,* S. Motsch, S. M. Kappler, "“, Angew. Chem. 2016, 128, 10300-10304 (doi: 10.1002/ange.201604921).

Formamides as Lewis Base Catalysts in SN-Reactions - Efficient Transformation of Alcohols into Chlorides, Amines and Ethers / Angew. Chem. Int. Ed. 2016, 55, 10145-10149 (doi: 10.1002/anie.201604921).

Highlighted in: Zhao, W.; Zhao, D.; Guizetti, S.; Schwindeman, J. A.; Daniels, D. S. B.; Guerrero, C.; Knight, J. Org. Process Res. Dev. 2016, 20, 1691-1701 (doi: 10.1021/acs.oprd.6b00321).

 

10. P. H. Huy, I. Filbrich (Saarland University), “Method of converting alcohol to halide”, LU patent 2017/93108 (Priority date 2016, June 16th).

 

9. P. H. Huy (Saarland University), “Method of converting alcohol to halide”, WO patent 2016/202894 A1 (Priority date 2015, June 17st).


Postdoc and PhD

2015

8. A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions / R. Opitz, M. Müller, C. Reuter, M. Barone, A. Soicke, Y. Roske, K. Piotukh, P. Huy, M. Beerbaum, B. Wiesner, M. Beyermann, P. Schmieder, C. Freund, R. Volkmer, H. Oschkinat, H.-G. Schmalz,* R. Kühne,* Proc. Natl. Acad. Sci. USA 2015, 112, 5011-5016 ( doi: 10.1073/pnas.1422054112).

2014

7. Concise, stereodivergent and highly stereoselective synthesis of cis- and trans-2-substituted 3-hydroxypiperidines – development of a phosphite-driven cyclodehydration / P. H. Huy,* J. Westphal, A. M. P. Koskinen,* Beilstein J. Org. Chem. 2014, 10, 369-383 (doi: 10.3762/bjoc.10.35).

2013

6. Efficient, Stereodivergent Access to 3-Piperidinols by traceless P(OEt)3-Cyclodehydration / P. H. Huy,* A. M. P. Koskinen,* Org. Lett. 2013, 15, 5178-5181 (doi 10.1021/ol4026588).

5. R. Kühne, H. Oschkinat, R. Opitz, M. Müller, H.-G. Schmalz, C. Reuter, P. Huy, "Structural mimetics of proline-rich peptides and use of the same“, WO patent 2013/030111 A1.

2011

4. Exercises in Pyrrolidine Chemistry: Gram Scale Synthesis of a Pro-Pro Dipeptide Mimetic with a Polyproline Type II Helix Conformation / C. Reuter, P. Huy, J.-M. Neudörfel, R. Kühne, H.-G. Schmalz,* Chem. Eur. J. 2011, 17, 12037-12044 (doi: 10.1002/chem.201101704).

3. Practical One-pot Double Functionalizations of Proline / P. Huy, H.-G. Schmalz,* Synthesis 2011, 954-960 (doi: 10.1055/s-0030-1258428).

2. A Practical Synthesis of trans-3-substituted Proline Derivatives through 1,4-Addition / P. Huy, J.-M. Neudörfl, H.-G. Schmalz,* Org. Lett. 2011, 13, 216-219 (doi: 10.1021/ol102613z).

2010

1. Adressierung von Protein-Protein-Wechselwirkungen durch niedermolekulare Verbindungen: ein Pro-Pro-Dipeptid-mimetikum mit PPII-Helixkonformation als Modul für die Synthese PRD-bindender Liganden / J. Zaminer, C. Brockmann, P. Huy, R. Opitz, C. Reuter, M. Beyermann, C. Freund, M. Müller, H. Oschkinat, R. Kühne,* H.-G. Schmalz,* Angew. Chem. 2010, 122, 7265–7269.

Addressing Protein–Protein Interactions with Small Molecules: A Pro-Pro Dipeptide Mimic with a PPII Helix Conformation as a Module for the Synthesis of PRD-Binding Ligands / Angew. Chem. Int. Ed. 2010, 49, 7111–7115 (doi: 10.1002/anie.20100173).